Article
Allelic variation at the TAP 1 locus influences disease phenotype in HLA-B27 positive individuals with ankylosing spondylitis.
Tissue antigens - 1 May 1995
Maksymowych W P, Tao S, Li Y, Wing M, Russell A S
Abstract excerpt
The objective was to determine the role of the TAP 1 gene in influencing the phenotype of disease in adult patients with ankylosing spondylitis (AS). The distribution of TAP 1 gene alleles was determined using the PCR RFLP method and restriction enzymes Bcl I and Acc I. The study population inclu...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP-Binding Cassette Transporters
- Adult
- Aged
- Alleles
- Base Sequence
- DNA Primers
- Female
- Gene Frequency
- Genetic Variation
- HLA-B27 Antigen
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Phenotype
- Spondylitis, Ankylosing