Article
TNF-α-308 polymorphism determines clinical manifestations and therapeutic response of ankylosing spondylitis in Han Chinese.
Medicina clinica - 20 Dec 2017
Ma Hai-Jun, Yin Qing-Feng, Wu Yin, Guo Ming-Hao
Abstract excerpt
BACKGROUND AND OBJECTIVE: There is ongoing debate as to whether tumor necrosis factor alpha (TNF-α)-308 is associated with ankylosing spondylitis (AS). The aim of the present study was to determine whether TNF-α-308 is involved into genetic susceptibility, clinical features and therapeutic response of AS in Han Chinese. METHODS: Two hundred and sixty AS patients with 260 ethnically matched healthy blood donors...
Topics
- Adolescent
- Adult
- Aged
- Anti-Inflammatory Agents
- Asian People
- Case-Control Studies
- Child
- China
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic
- Retrospective Studies