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Article

The -308.1 polymorphism in the promoter region of the tumor necrosis factor gene is associated with ankylosing spondylitis independent of HLA-B27.

The Journal of rheumatology - 1 May 1999

McGarry F, Walker R, Sturrock R, Field M

Abstract excerpt

OBJECTIVE: To investigate the allele frequencies of 6 polymorphic sites spanning the region of the genome close to the tumor necrosis factor (TNF) gene in a group of HLA-B27 positive patients with ankylosing spondylitis (AS) in the West of Scotland. METHODS: One hundred sixty-seven patients with AS, 93 healthy controls, and 88 HLA-B27 positive healthy controls, all from the West of Scotland, were typed by...

Read the complete abstract on PubMed

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Share to Gene Frequency
Share to Genetic Markers
Share to HLA-B27 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microsatellite Repeats

Share to Polymorphism, Restriction Fragment Length

Share to Promoter Regions, Genetic

Share to Spondylitis, Ankylosing

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 10332976

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The -308.1 polymorphism in the promoter region of the tumor necrosis factor gene is associated with ankylosing spondylitis independent of HLA-B27.PMID 10332976Read ↗

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