Article
Polymorphisms, but lack of mutations or instability, in the promotor region of the mitochondrial genome in human colonic tumors.
Cancer research - 15 Jul 1994
Heerdt B G, Chen J, Stewart L R, Augenlicht L H
Abstract excerpt
The region of the human mitochondrial D-loop has been sequenced from DNA of colonic tumors and paired normal colonic tissue to determine if mutations in the promotors for the heavy or light strands are responsible for the decrease in mitochondrial gene expression present in colonic tumors. No mutations were detected in the colonic tumors, but new polymorphisms, including a sequence analogous to CA microsatellites...
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