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Article

UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor.

Cancer research - 15 Jul 1994

Orr R B, Kamen B A

Abstract excerpt

Some cells accumulate folate via a receptor-coupled process termed potocytosis. The folate receptor, a glycosyl phosphatidylinositol anchored M(r) 38,000-39,000 glycoprotein, is coded for by at least two genes (FR alpha and FR beta) at 11q13. The karyotype of UMSCC38, a human squamous cell carcinoma cell line, suggests that it may contain multiple copies of the folate receptor gene(s). Southern blot analysis...

Topics

Base Sequence
Biological Transport
Carcinoma, Squamous Cell
Carrier Proteins
Chromosomes, Human, Pair 11
DNA, Complementary
Folate Receptors, GPI-Anchored
Folic Acid
Gene Amplification
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Receptors, Cell Surface

Tetrahydrofolates

Tumor Cells, Cultured

Source

Identifiers

PMID: 8033114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8033114-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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