Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?

International journal of cancer - 15 Jul 2006

Kelemen Linda E

Abstract excerpt

Folate receptor alpha (FRalpha) is a membrane-bound protein with high affinity for binding and transporting physiologic levels of folate into cells. Folate is a basic component of cell metabolism and DNA synthesis and repair, and rapidly dividing cancer cells have an increased requirement for folate to maintain DNA synthesis, an observation supported by the widespread use of antifolates in cancer chemotherapy....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Canada
Share to Cytosol
Share to Dietary Supplements

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Folic Acid

Share to Gonadal Steroid Hormones

Share to Homocysteine

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 16453285
DOI: 10.1002/ijc.21712

Genes

FOLR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?PMID 16453285Read ↗

Emerging roles for folate receptor FOLR1 in signaling and cancerSemantic proximity Read ↗

Folate Receptor Alpha in Advanced Epithelial Ovarian Cancer: Diagnostic Role and Therapeutic Implications of a Clinically Validated BiomarkerSemantic proximity Read ↗

Role of folate receptor genes in reproduction and related cancersSemantic proximity Read ↗

Molecular mechanisms underlying the potentially adverse effects of folateSemantic proximity Read ↗

Paradoxical Impact of Two Folate Receptors, FRα and RFC, in Ovarian Cancer: Effect on Cell Proliferation, Invasion and Clinical OutcomeSemantic proximity Read ↗

How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.Semantic proximity Read ↗

High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation.Semantic proximity Read ↗

Folate receptor alpha protein expression in ovarian serous cystadenocarcinoma tumors of The Cancer Genome Atlas: exploration beyond single-agent therapySemantic proximity Read ↗

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implicationsSemantic proximity Read ↗

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesisSemantic proximity Read ↗

The impact of folate status on the efficacy of colorectal cancer treatment.Semantic proximity Read ↗

Folic acid deficiency and cancer: mechanisms of DNA instabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.