Identification of a point mutation in the folate receptor gene that confers a dominant negative phenotype.

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Article

Identification of a point mutation in the folate receptor gene that confers a dominant negative phenotype.

Cancer research - 15 Feb 1995

Orr R B, Kamen B A

Abstract excerpt

UM-SCC-38 cells, a squamous cell carcinoma cell line of the head and neck, express limited amounts of folate receptor alpha antigen which is not capable of binding either folic acid or 5-methyltetrahydrofolic acid. Three distinct mutations in the open reading frame of the folate receptor were ide...

Topics

Animals
CHO Cells
Carcinoma, Squamous Cell
Carrier Proteins
Cricetinae
DNA, Complementary
Folate Receptors, GPI-Anchored
Folic Acid
Genes, Dominant
Glycosylphosphatidylinositols
Haplorhini
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Point Mutation

Receptors, Cell Surface

Tetrahydrofolates

Transfection

Tritium

Source

Open in PubMed

Identifiers

PMID: 7850798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7850798-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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