Article
Identification of a point mutation in the folate receptor gene that confers a dominant negative phenotype.
Cancer research - 15 Feb 1995
Orr R B, Kamen B A
Abstract excerpt
UM-SCC-38 cells, a squamous cell carcinoma cell line of the head and neck, express limited amounts of folate receptor alpha antigen which is not capable of binding either folic acid or 5-methyltetrahydrofolic acid. Three distinct mutations in the open reading frame of the folate receptor were identified. We now show that the three mutants are nonfunctional with respect to folic acid binding because the protein...
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