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Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition

9 Aug 2013

Abstract excerpt

Antifolates, folate analogs that inhibit vitamin B9 (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake of the antifolates in clinical use occurs primarily via widely expressed facilitative membrane transporters. More recently, human folate receptors (FRs), high affinity receptors that transport folate via endocytosis,...

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PMID: 23934049
DOI: 10.1073/pnas.1308827110

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