Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21ras peptide presented by HLA-A*0201.

doi:10.1002/ijc.2910610319

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Article

Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21ras peptide presented by HLA-A*0201.

International journal of cancer - 4 May 1995

Van Elsas A, Nijman H W, Van der Minne C E, Mourer J S, Kast W M, Melief C J, Schrier P I

Abstract excerpt

The ras oncogene is frequently found to be activated in human cancer through point mutations at codons 12, 13 or 61. We explored whether these altered p21ras protein sequences contain peptide sequences that can activate naive CD8+ cytotoxic T lymphocytes (CTL). Several wild-type and mutated p21ra...

Topics

Alleles
Amino Acid Sequence
CD8-Positive T-Lymphocytes
Cell Line
Cytotoxicity, Immunologic
HLA-A Antigens
Humans
Kinetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Melanoma
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Protein Binding

Proto-Oncogene Proteins p21(ras)

Recombinant Proteins

T-Lymphocytes, Cytotoxic

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7729952
DOI: 10.1002/ijc.2910610319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7729952-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21ras peptide presented by HLA-A*0201.PMID 7729952Read ↗

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