Article
Cytotoxic T-lymphocyte responses against mutated p21 ras peptides: an analysis of specific T-cell-receptor gene usage.
International journal of cancer - 15 Nov 1996
Juretic A, Jürgens-Göbel J, Schaefer C, Noppen C, Willimann T E, Kocher T, Zuber M, Harder F, Heberer M, Spagnoli G C
Abstract excerpt
Generation of cytotoxic-T-lymphocyte (CTL) responses against mutated ras peptides from peripheral-blood mononuclear cells (PBMC) was attempted in a group of HLA-A2.1+ healthy donors. Bulk PBMC cultures were stimulated in vitro with a mixture of peptides encompassing 12 Gly --> Val, 61 Gln --> Lys...
Topics
- Amino Acid Sequence
- Base Sequence
- Humans
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins p21(ras)
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured