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Mechanisms and strategies to overcome multiple drug resistance in cancer

17 Feb 2006

Abstract excerpt

One of the major problems in chemotherapy is multidrug resistance (MDR) against anticancer drugs. ATP-binding cassette (ABC) transporters are a family of proteins that mediate MDR via ATP-dependent drug efflux pumps. Many MDR inhibitors have been identified, but none of them have been proven clinically useful without side effects. Efforts continue to discover not toxic MDR inhibitors which lack pharmacokinetic...

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PMID: 16497299
DOI: 10.1016/j.febslet.2006.02.020

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