Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P-glycoprotein expression in Ehrlich ascites tumour cells after in vitro and in vivo selection with daunorubicin.

British journal of cancer - 1 Nov 1998

Nielsen D, Eriksen J, Maare C, Jakobsen A H, Skovsgaard T

Abstract excerpt

Fluctuation analysis experiments were performed to assess whether selection or induction determines expression of P-glycoprotein and resistance in the murine Ehrlich ascites tumour cell line (EHR2) after exposure to daunorubicin. Thirteen expanded populations of EHR2 cells were exposed to daunorubicin 7.5 x 10(-9) M or 10(-8) M for 2 weeks. Surviving clones were scored and propagated. Only clones exposed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Daunorubicin

Share to Drug Resistance, Neoplasm

Share to Mice, Inbred DBA

Share to Mutation

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 9820176
DOI: 10.1038/bjc.1998.650
PMCID: PMC2063003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

P-glycoprotein expression in Ehrlich ascites tumour cells after in vitro and in vivo selection with daunorubicin.PMID 9820176Read ↗

Influence of chemosensitizers on resistance mechanisms in daunorubicin-resistant Ehrlich ascites tumour cells.Semantic proximity Read ↗

Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis.Semantic proximity Read ↗

Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.Semantic proximity Read ↗

Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.Semantic proximity Read ↗

Effect of verapamil on daunorubicin accumulation in human leukemic cells with different levels of MDR1 gene expression.Semantic proximity Read ↗

MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells.Semantic proximity Read ↗

Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection?Semantic proximity Read ↗

P‐glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.