Article
P-glycoprotein expression in Ehrlich ascites tumour cells after in vitro and in vivo selection with daunorubicin.
British journal of cancer - 1 Nov 1998
Nielsen D, Eriksen J, Maare C, Jakobsen A H, Skovsgaard T
Abstract excerpt
Fluctuation analysis experiments were performed to assess whether selection or induction determines expression of P-glycoprotein and resistance in the murine Ehrlich ascites tumour cell line (EHR2) after exposure to daunorubicin. Thirteen expanded populations of EHR2 cells were exposed to daunoru...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antibiotics, Antineoplastic
- Carcinoma, Ehrlich Tumor
- Daunorubicin
- Drug Resistance, Neoplasm
- Female
- Mice
- Mice, Inbred DBA
- Mutation
- Tumor Cells, Cultured