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Article

Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway.

The Journal of biological chemistry - 12 Dec 2003

Mohapatra Durga P, Nau Carla

Abstract excerpt

Proinflammatory prostaglandin E2 is known to sensitize sensory neurons to noxious stimuli. This sensitization is mediated by the cAMP-dependent protein kinase (PKA) signal pathway. The capsaicin receptor TRPV1, a non-selective cation channel of sensory neurons involved in the sensation of inflammatory pain, is a target of PKA-mediated phosphorylation. Our goal was to investigate the influence of PKA on...

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Source

Identifiers

PMID: 14506258
DOI: 10.1074/jbc.M306619200

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway.PMID 14506258Read ↗

cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.Semantic proximity Read ↗

Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.Semantic proximity Read ↗

A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents.Semantic proximity Read ↗

Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.Semantic proximity Read ↗

Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors.Semantic proximity Read ↗

TRPV1.Semantic proximity Read ↗

Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization.Semantic proximity Read ↗

Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.Semantic proximity Read ↗

Acid potentiation of the capsaicin receptor determined by a key extracellular site.Semantic proximity Read ↗

TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization.Semantic proximity Read ↗

Modality-specific mechanisms of protein kinase C-induced hypersensitivity of TRPV1: S800 is a polymodal sensitization site.Semantic proximity Read ↗

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.Semantic proximity Read ↗

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