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Article

Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations.

Neurology - 10 Dec 2013

Pfeffer Gerald, Burke Ailbhe, Yu-Wai-Man Patrick, Compston D Alastair S, Chinnery Patrick F

Abstract excerpt

OBJECTIVE: To determine whether the association between multiple sclerosis (MS) and Leber hereditary optic neuropathy (LHON) (known as "Harding disease") is a chance finding, or the 2 disorders are mechanistically linked. METHODS: We performed a United Kingdom-wide prospective cohort study of prevalent cases of MS with LHON mitochondrial DNA (mtDNA) mutations. The new cases were compared with published cases,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24198293
DOI: 10.1212/01.wnl.0000437308.22603.43
PMCID: PMC3863351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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