Article
Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation.
Brain : a journal of neurology - 1 Aug 1992
Harding A E, Sweeney M G, Miller D H, Mumford C J, Kellar-Wood H, Menard D, McDonald W I, Compston D A
Abstract excerpt
Eight women are described who presented with bilateral, usually sequential, optic neuropathy, six of whom later developed a neurological syndrome indistinguishable from multiple sclerosis (MS). Magnetic resonance imaging, performed in five of the patients with an MS-like illness and in the two others with optic neuropathy alone, showed widespread white matter lesions as seen in MS. All of these women had...
Topics
- Adult
- DNA, Mitochondrial
- Female
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Magnetic Resonance Imaging
- Middle Aged
- Multiple Sclerosis
- Mutation
- Optic Atrophies, Hereditary