Article
Leber's hereditary optic neuropathy mitochondrial DNA mutations in familial multiple sclerosis.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Apr 1999
Mojon D S, Fujihara K, Hirano M, Miller C, Lincoff N S, Jacobs L D, Greenberg S J
Abstract excerpt
Leber's hereditary optic neuropathy (LHON) can be difficult to distinguish from optic neuritis due to multiple sclerosis (MS). For several decades an association of LHON and MS has been suspected, and within the past 7 years the LHON nucleotide (nt)-3460 and nt-11778 mtDNA mutations have been identified in several patients with MS-like phenotypes. To further study this association, we tested 42 index patients...
Topics
- Adult
- Aged
- Confidence Intervals
- DNA
- DNA, Mitochondrial
- Diagnosis, Differential
- Female
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
- Optic Atrophies, Hereditary
- Phenotype