Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening for Leber's hereditary optic neuropathy associated mitochondrial DNA mutations in patients with prominent optic neuritis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jan 1997

Kalman B, Rodriguez-Valdez J L, Bosch U, Lublin F D

Abstract excerpt

Previous case reports demonstrated the presence of Leber's hereditary optic neuropathy (LHON) associated mitochondrial (mt) DNA mutations in patients presenting with prominent optic neuritis (PON). By screening the mtDNA, we have excluded the presence of these mutations in 22 patients with PON, indicating that the frequency of these mutations is less than 4.5% in our selected patient population. Reviewing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiple Sclerosis

Share to Mutation

Share to Optic Atrophies, Hereditary

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 9065918
DOI: 10.1177/135245859700200603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening for Leber's hereditary optic neuropathy associated mitochondrial DNA mutations in patients with prominent optic neuritis.PMID 9065918Read ↗

Leber's hereditary optic neuropathy mitochondrial DNA mutations in familial multiple sclerosis.Semantic proximity Read ↗

Clinical, biochemical and molecular genetic features of Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Mitochondrial abnormalities in patients with LHON-like optic neuropathies.Semantic proximity Read ↗

No evidence of association between optic neuritis and secondary LHON mtDNA mutations in patients with multiple sclerosis.Semantic proximity Read ↗

Mitochondrial changes in leukocytes of patients with optic neuritis.Semantic proximity Read ↗

Characterization of the mitochondrial genome in childhood multiple sclerosis. II. Multiple sclerosis without optic neuritis and LHON-associated genes.Semantic proximity Read ↗

Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations.Semantic proximity Read ↗

Detection of mitochondrial DNA mutations associated with leber hereditary optic neuropathy.Semantic proximity Read ↗

Analysis of the entire mitochondrial genome reveals Leber's hereditary optic neuropathy mitochondrial DNA mutations in an Arab cohort with multiple sclerosis.Semantic proximity Read ↗

Leber's hereditary optic neuropathy: clinical and molecular genetic aspects. Preliminary results in our families.Semantic proximity Read ↗

Leber's hereditary optic neuropathy mitochondrial DNA mutations in multiple sclerosis.Semantic proximity Read ↗

Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.