Article
Screening for Leber's hereditary optic neuropathy associated mitochondrial DNA mutations in patients with prominent optic neuritis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jan 1997
Kalman B, Rodriguez-Valdez J L, Bosch U, Lublin F D
Abstract excerpt
Previous case reports demonstrated the presence of Leber's hereditary optic neuropathy (LHON) associated mitochondrial (mt) DNA mutations in patients presenting with prominent optic neuritis (PON). By screening the mtDNA, we have excluded the presence of these mutations in 22 patients with PON, i...
Topics
- Adult
- DNA, Mitochondrial
- Female
- Genetic Testing
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
- Mutation
- Optic Atrophies, Hereditary
- Optic Neuritis
- Polymorphism, Genetic
- Vision Disorders