Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.

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Article

Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.

The Journal of biological chemistry - 15 Jun 1990

Ogami K, Hadzopoulou-Cladaras M, Cladaras C, Zannis V I

Abstract excerpt

We have mapped the promoter elements required for hepatic and intestinal transcription of the human apoCIII gene by deletion, nucleotide substitution, and DNase I footprinting analyses of the promoter region (nucleotides -1411 to +24). Deletion of the region -1020 to -871 increased 2-fold intestinal transcription without affecting hepatic transcription. Deletion of the region -890 to -686 decreased hepatic and...

Topics

Animals
Apolipoprotein C-III
Apolipoproteins C
Base Sequence
Carcinoma, Hepatocellular
Cell Line
Cell Nucleus
Chromosome Deletion
Colonic Neoplasms
Genes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intestinal Mucosa

Liver

Liver Neoplasms

Male

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Source

Open in PubMed

Identifiers

PMID: 2161843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2161843-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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