Article
Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.
The Journal of biological chemistry - 15 Jun 1990
Ogami K, Hadzopoulou-Cladaras M, Cladaras C, Zannis V I
Abstract excerpt
We have mapped the promoter elements required for hepatic and intestinal transcription of the human apoCIII gene by deletion, nucleotide substitution, and DNase I footprinting analyses of the promoter region (nucleotides -1411 to +24). Deletion of the region -1020 to -871 increased 2-fold intestinal transcription without affecting hepatic transcription. Deletion of the region -890 to -686 decreased hepatic and...
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