Article
Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells.
The Journal of biological chemistry - 15 Jun 1990
Metzger S, Leff T, Breslow J L
Abstract excerpt
ApoB-100, the major protein of low density lipoprotein, is produced primarily in the liver. The apoB promoter region from -86 to -52 binds two hepatic nuclear proteins. The protein that binds to the sequence between -86 to -61, called AF-1, was characterized and also shown to interact with the apoCIII, apoA-I, and apoCII promoters. We now show that the second protein, which by DNase I footprinting binds to the...
Topics
- Apolipoprotein B-100
- Apolipoproteins B
- Base Sequence
- CCAAT-Enhancer-Binding Proteins
- Cell Line
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes
- Humans
- Molecular Sequence Data
- Mutation