Article
Adenine for guanine substitution -78 base pairs 5' to the apolipoprotein (APO) A-I gene: relation with high density lipoprotein cholesterol and APO A-I concentrations.
Clinical genetics - 1 Dec 1993
Civeira F, Pocovi M, Cenarro A, Garces C, Ordovas J M
Abstract excerpt
A common mutation, adenine (A) for guanidine (G) substitution (G/A) has been located -78 bp 5' to the apo A-I gene. This region has been shown to be involved in the transcriptional regulation of the apo A-I gene. Previous studies have shown that this mutation is associated with altered high density lipoprotein cholesterol (HDL-C) levels, although these findings have not been consistent. We have studied the...
Topics
- Adult
- Apolipoprotein A-I
- Base Sequence
- Cholesterol
- Cholesterol, HDL
- DNA
- Female
- Gene Frequency
- Genotype
- Humans
- Lipoproteins
- Male