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Article

Mutational spectrum in the p53 gene in bladder tumors from the endemic area of black foot disease in Taiwan.

Carcinogenesis - 1 Jun 1994

Shibata A, Ohneseit P F, Tsai Y C, Spruck C H, Nichols P W, Chiang H S, Lai M K, Jones P A

Abstract excerpt

An elevated risk of bladder cancer has been reported in the endemic region of 'black foot disease' on the southwest coast of Taiwan and may be related to high arsenic levels in artesian well water. Thirteen urothelial tumors from this endemic region were examined for mutations in exons 5-8 of the p53 gene to identify the effects of possible exogenous factors at the DNA level. DNA was extracted from archival...

Topics

Adult
Aged
Arsenic Poisoning
Carcinoma, Transitional Cell
Female
Foot Diseases
Genes, p53
Humans
Male
Middle Aged
Mutation
Peripheral Vascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poisoning

Taiwan

Urinary Bladder Neoplasms

Source

Identifiers

PMID: 8020137
DOI: 10.1093/carcin/15.6.1085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8020137-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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