Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan.

doi:10.1038/sj.bjc.6690467

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan.

British journal of cancer - 1 Jun 1999

Hsu C H, Yang S A, Wang J Y, Yu H S, Lin S R

Abstract excerpt

To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinomas (SCC). The result showed that p53 gene mutations were found in 39% of cases with Bowen's...

Topics

Aged
Arsenic
Bowen's Disease
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
DNA Mutational Analysis
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

Source

Open in PubMed Open full text

Identifiers

PMID: 10362120
DOI: 10.1038/sj.bjc.6690467
PMCID: PMC2363055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin Neoplasms

Taiwan

Tumor Suppressor Protein p53

Water Pollutants, Chemical