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Article

High rate of morphological reversion in tumor cell line H-19 associated with permanent transcriptional suppression of the LTR, v-src, LTR provirus.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1994

Hejnar J, Svoboda J, Geryk J, Fincham V J, Hák R

Abstract excerpt

The highly malignant line of morphologically transformed H-19 hamster tumor cells that harbor a single LTR, v-src, LTR provirus segregates morphologically flat revertants at the rate of 1.4 to 2.4 x 10(-3)/cell/cycle. Revertants behave like almost nonmalignant cells; they keep the provirus within an unaltered junction DNA fragment. However, the provirus is methylated, permanently transcriptionally silent, and not...

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PMID: 8018560

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