Article
High rate of morphological reversion in tumor cell line H-19 associated with permanent transcriptional suppression of the LTR, v-src, LTR provirus.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1994
Hejnar J, Svoboda J, Geryk J, Fincham V J, Hák R
Abstract excerpt
The highly malignant line of morphologically transformed H-19 hamster tumor cells that harbor a single LTR, v-src, LTR provirus segregates morphologically flat revertants at the rate of 1.4 to 2.4 x 10(-3)/cell/cycle. Revertants behave like almost nonmalignant cells; they keep the provirus within...
Topics
- Animals
- Base Sequence
- Cell Line, Transformed
- Chick Embryo
- Chickens
- Cricetinae
- Genes, src
- Mesocricetus
- Molecular Sequence Data
- Mutation
- Proviruses
- Repetitive Sequences, Nucleic Acid
- Suppression, Genetic
- Time Factors
- Transcription, Genetic
- Virus Integration