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Article

Abnormalities in p53 and DNA content in transitional cell carcinoma of the bladder.

British journal of urology - 1 May 1994

Mellon K, Wilkinson S, Vickers J, Robinson M C, Shenton B K, Neal D E

Abstract excerpt

OBJECTIVE: To determine if transitional cell tumours of the bladder which contain mutations in the p53 gene have alterations in their DNA content. MATERIALS AND METHODS: In 33 transitional cell tumours of the bladder, DNA content was determined by flow cytometry and compared with expression of mutant p53 as assessed by immuno-histochemistry. RESULTS: Abnormal DNA content was associated with increased staining for...

Topics

Carcinoma, Transitional Cell
DNA, Neoplasm
Humans
Immunoenzyme Techniques
Mutation
Neoplasm Proteins
Neoplasm Staging
Ploidies
Prognosis
Tumor Suppressor Protein p53
Urinary Bladder Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8012774
DOI: 10.1111/j.1464-410x.1994.tb07637.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8012774-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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