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Article

Mutation spectrum of cigarette smoke condensate in Salmonella: comparison to mutations in smoking-associated tumors.

Carcinogenesis - 1 Oct 1995

DeMarini D M, Shelton M L, Levine J G

Abstract excerpt

We used colony probe hybridization and polymerase chain reaction/DNA sequence analysis to determine the mutations in approximately 1600 revertants of Salmonella induced by cigarette smoke condensate (CSC) in the presence of S9. CSC induced approximately 80% GC-->TA transversions and approximately 20% GC-->AT transitions at the base-substitution allele (hisG46) in strain TA100. This spectrum was similar to those...

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PMID: 7586163
DOI: 10.1093/carcin/16.10.2535

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PAH

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