Article
The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolisers of debrisoquine.
British journal of clinical pharmacology - 1 Apr 1994
Ashforth E I, Palmer J L, Bye A, Bedding A
Abstract excerpt
The pharmacokinetics of the 5-HT3 receptor antagonist ondansetron following an 8 mg i.v. dose were investigated in 12 subjects previously phenotyped with debrisoquine. Six subjects were poor metabolisers (debrisoquine metabolic ratios 29-131) and six were extensive metabolisers (debrisoquine meta...
Topics
- Adult
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Female
- Half-Life
- Humans
- Infusions, Intravenous
- Male
- Metabolic Clearance Rate
- Mixed Function Oxygenases
- Ondansetron
- Phenotype