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Article

Quantitative pharmacogenetics of nortriptyline: a novel approach.

Clinical pharmacokinetics - 1 Jan 2001

Kvist E E, Al-Shurbaji A, Dahl M L, Nordin C, Alván G, Ståhle L

Abstract excerpt

OBJECTIVE: To quantitatively model nortriptyline clearance as a function of the cytochrome P450 (CYP) 2D6 genotype and to estimate the contribution of genotype to the interindividual variability in steady-state plasma concentration and metabolic clearance. DESIGN: Modelling study using data from two previously published studies. PARTICIPANTS: 20 healthy volunteers receiving single oral doses of nortriptyline and...

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Source

Identifiers

PMID: 11735606
DOI: 10.2165/00003088-200140110-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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