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Article

Antitumor mechanisms when pRb and p53 are genetically inactivated.

Oncogene - 27 Aug 2015

Zhu L, Lu Z, Zhao H

Abstract excerpt

pRb and p53 are the two major tumor suppressors. Their inactivation is frequent when cancers develop and their reactivation is rationale of most cancer therapeutics. When pRb and p53 are genetically inactivated, cells irreparably lose the antitumor mechanisms afforded by them. Cancer genome studies document recurrent genetic inactivation of RB1 and TP53, and the inactivation becomes more frequent in more advanced...

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Share to Carcinogenesis
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Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Retinoblastoma Protein

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Identifiers

PMID: 25486431
DOI: 10.1038/onc.2014.399
PMCID: PMC4459916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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