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Article

Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery

20 Jun 2012

Abstract excerpt

The retinoblastoma (RB) family consists of three genes, RB1, RBL1, and RBL2, that code for the pRb, p107, and pRb2/p130 proteins, respectively. All these factors have pivotal roles in controlling fundamental cellular mechanisms such as cell cycle, differentiation and apoptosis. The founder and the most investigated RB family protein is pRb, which is considered to be the paradigm of tumor suppressors. However,...

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PMID: 22718244
DOI: 10.1002/jcp.24137

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