[Mechanisms for inactivation of tumor suppressor genes].

Article

[Mechanisms for inactivation of tumor suppressor genes].

Nihon rinsho. Japanese journal of clinical medicine - 1 Nov 1995

Ishizaki K

Abstract excerpt

Tumor suppressor genes are inactivated by various mechanisms. Since a mutant allele of a tumor suppressor gene is recessive for cellular malignant transformation, mutation is heritable and germ line mutations of tumor suppressor genes such as retinoblastoma gene and p53 gene are well characterize...

Topics

Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Genes, Tumor Suppressor
Genes, p53
Heterozygote
Humans
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.