[Mechanisms for inactivation of tumor suppressor genes].

Abstract excerpt

Tumor suppressor genes are inactivated by various mechanisms. Since a mutant allele of a tumor suppressor gene is recessive for cellular malignant transformation, mutation is heritable and germ line mutations of tumor suppressor genes such as retinoblastoma gene and p53 gene are well characterized. In the process of loss-of-function of a tumor suppressor gene, chromosome type of mutations are often involved,...

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