Article
Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors.
Antimicrobial agents and chemotherapy - 1 Aug 1995
Tisdale M, Myers R E, Maschera B, Parry N R, Oliver N M, Blair E D
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) protease inhibitor-resistant variants, isolated on passage of HIV-1HXB2 in MT-4 cells with five different protease inhibitors, have been examined for cross-resistance to five inhibitors. The protease inhibitors studied were Ro 31-8959, A-77003, XM323, L-735,524, and VX-478. Resistant variants with two to four mutations within their protease sequence and 9- to...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Drug Resistance, Microbial
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction