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Article

<i>MDR1</i> Gene Expression in Brain of Patients with Medically Intractable Epilepsy

1 Jan 1995

Abstract excerpt

Why some patients with seizures are successfully treated with antiepileptic drugs (AEDs) and others prove medically intractable is not known. Inadequate intraparenchymal drug concentration is a possible mechanism of resistance to AEDs. The multiple drug resistance gene (MDR1) encodes P-glycoprotein, an energy-dependent efflux pump that exports planar hydrophobic molecules from the cell. If P-glycoprotein is...

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Identifiers

PMID: 8001500
DOI: 10.1111/j.1528-1157.1995.tb01657.x

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