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Article

Intractable epilepsy and the P-glycoprotein hypothesis

22 May 2015

Abstract excerpt

Epilepsy is a serious neurological disorder that affects more than 60 million people worldwide. Intractable epilepsy (IE) refers to approximately 20%-30% of epileptic patients who fail to achieve seizure control with antiepileptic drug (AED) treatment. Although the mechanisms underlying IE are not well understood, it has been hypothesized that multidrug transporters such as P-glycoprotein (P-gp) play a major role...

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PMID: 26000919
DOI: 10.3109/00207454.2015.1038710

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