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Article

Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions.

Drug metabolism and drug interactions - 1 Jan 2011

Lazarowski Alberto, Czornyj Liliana

Abstract excerpt

Epilepsy is a common neurological disorder. About one-third of epilepsy patients have a multidrug resistance (MDR) phenotype and develop refractory epilepsy (RE). Changes in the properties of the antiepileptic drugs (AEDs) targets resulting in reduced drug sensitivity, can't explain the MDR phenotype. This particular refractoriness is now attributed to overexpression of multidrug transporters in brain, leading to...

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Source

Identifiers

PMID: 21557674
DOI: 10.1515/DMDI.2011.006

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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