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Article

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

1 Jan 2002

Abstract excerpt

Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively. Amongst the various resistance mechanisms, overexpression of drug resistance proteins, such as multi-drug resistance gene-1 P-glycoprotein (MDR1) and multidrug resistance-associated protein 1 (MRP1), has been shown to...

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PMID: 11834590
DOI: 10.1093/brain/awf002

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