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Article

Significance of MDR1 and multiple drug resistance in refractory human epileptic brain

9 Oct 2004

Abstract excerpt

BACKGROUND: The multiple drug resistance protein (MDR1/P-glycoprotein) is overexpressed in glia and blood-brain barrier (BBB) endothelium in drug refractory human epileptic tissue. Since various antiepileptic drugs (AEDs) can act as substrates for MDR1, the enhanced expression/function of this protein may increase their active extrusion from the brain, resulting in decreased responsiveness to AEDs. METHODS: Human...

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PMID: 15473912
DOI: 10.1186/1741-7015-2-37

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