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Article

Drug resistance in epilepsy: Why is a simple explanation not enough?

1 Dec 2007

Abstract excerpt

To the Editor: The issue of pharmacoresistance in epilepsy has received considerable attention in recent years, and the search for mechanisms that might explain why around 30% of patients fail to respond to current medications continues apace. A number of plausible hypotheses have been proposed, including inadequate penetration of antiepileptic drugs (AEDs) across the blood–brain barrier (BBB); acquired...

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PMID: 18088269
DOI: 10.1111/j.1528-1167.2007.01260_2.x

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