Article

Role of Permeability glycoprotein (P-gp) and Multidrug resistance protein 1 (MRP-1) in drug-resistance in mesial temporal lobe epilepsy

2021-01-23

Abstract excerpt

About 30% of patients with epilepsy do not respond to anti-epileptic drugs leading to refractory seizures. The pathogenesis of drug-resistance in Mesial Temporal Lobe Epilepsy (MTLE) is not completely understood. Increased activity of drug-efflux transporters might be involved, resulting in subclinical concentrations of the drug at the target site. The major drug-efflux transporters are permeability glycoprotein (...

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Literature Corpus work: 1fd83048-3db6-5980-98bf-70633c67d00f
DOI: 10.22541/au.161142051.19089910/v1

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