Article
Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments.
Cell - 2 Dec 1994
Hahne K, Haucke V, Ramage L, Schatz G
Abstract excerpt
The S. cerevisiae gene MCR1 encodes two mitochondrial isoforms of NADH-cytochrome b5 reductase. The primary translation product has an amino-terminal matrix-targeting signal, followed by a stretch of 21 uncharged amino acids. This precursor protein is inserted into the outer membrane, but only ab...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- Cell Compartmentation
- Cell Nucleus
- Cytochrome Reductases
- Cytochrome-B(5) Reductase
- Endopeptidases
- Gene Dosage
- Genes, Fungal
- Intracellular Membranes
- Isoenzymes
- Mitochondria
- Mitochondrial Proteins
- Models, Biological
- Molecular Sequence Data
- Mutation
- Protein Processing, Post-Translational