Article
Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism.
Cell - 29 May 1992
Glick B S, Brandt A, Cunningham K, Müller S, Hallberg R L, Schatz G
Abstract excerpt
The pathway by which cytochromes c1 and b2 reach the mitochondrial intermembrane space has been controversial. According to the "conservative sorting" hypothesis, these proteins are first imported across both outer and inner membranes into the matrix, and then are retranslocated across the inner membrane. Our data argue against this model: import intermediates of cytochromes c1 and b2 were found only outside the...
Topics
- Adenosine Triphosphate
- Chaperonin 60
- Cytochrome c Group
- Endopeptidase K
- Heat-Shock Proteins
- Intracellular Membranes
- L-Lactate Dehydrogenase
- L-Lactate Dehydrogenase (Cytochrome)
- Mitochondria
- Models, Biological