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Genetic versus antigenic differences among highly pathogenic H5N1 avian influenza A viruses: Consequences for vaccine strain selection.

Virology - 1 Mar 2017

Peeters Ben, Reemers Sylvia, Dortmans Jos, de Vries Erik, de Jong Mart, van de Zande Saskia, Rottier Peter J M, de Haan Cornelis A M

Abstract excerpt

Highly pathogenic H5N1 avian influenza A viruses display a remarkable genetic and antigenic diversity. We examined to what extent genetic distances between several H5N1 viruses from different clades correlate with antigenic differences and vaccine performance. H5-specific antisera were generated, and cross-reactivity and antigenic distances between 12 different viruses were determined. In general, antigenic...

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PMID: 28135661
DOI: 10.1016/j.virol.2017.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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