Article
In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001
Sale J E, Bemark M, Williams G T, Jolly C J, Ehrenstein M R, Rada C, Milstein C, Neuberger M S
Abstract excerpt
Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. Here we compare the contributions of class-switch...
Topics
- Animals
- Base Pairing
- Biological Transport
- DNA Damage
- GC Rich Sequence
- Genes, myc
- Humans
- Immunoglobulin Class Switching
- Immunoglobulin Isotypes
- Immunoglobulins
- Mutation