Microsatellite analysis at 1p36.3 in malignant melanoma of the skin: fine mapping in search of a possible tumour suppressor gene region.

doi:10.1097/00008390-200302000-00006

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Article

Microsatellite analysis at 1p36.3 in malignant melanoma of the skin: fine mapping in search of a possible tumour suppressor gene region.

Melanoma research - 1 Feb 2003

Poetsch Micaela, Dittberner Thomas, Woenckhaus Christian

Abstract excerpt

Deletions in 1p36 in malignant melanoma have been found in high percentages in nodular melanomas and melanoma metastases. Despite many efforts, no candidate tumour suppressor gene associated with malignant melanoma has so far been found in this region. To further determine a possible tumour suppressor gene locus, we carried out a deletion mapping of chromosome 1p36 at nine microsatellite loci in 74 malignant...

Topics

Alleles
Chromosomes, Human, Pair 1
DNA, Neoplasm
Genes, Tumor Suppressor
Humans
Loss of Heterozygosity
Melanoma
Microsatellite Repeats
Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 12569282
DOI: 10.1097/00008390-200302000-00006

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