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Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice

20 Jan 2020

Abstract excerpt

Abstract Ionising radiation (IR) is a recognised carcinogen responsible for cancer development in patients previously treated using radiotherapy, and in individuals exposed as a result of accidents at nuclear energy plants. However, the mutational signatures induced by distinct types and doses of radiation are unknown. Here, we analyse the genetic architecture of mammary tumours, lymphomas and sarcomas induced by...

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PMID: 31959748
DOI: 10.1038/s41467-019-14261-4

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