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Article

Association between apolipoprotein E4 and cognitive decline in elderly adults.

Journal of the American Geriatrics Society - 1 Nov 2007

Packard Chris J, Westendorp Rudi G J, Stott David J, Caslake Muriel J, Murray Heather M, Shepherd James, Blauw Gerard J, Murphy Michael B, Bollen Edward L E M, Buckley Brendan M, Cobbe Stuart M, Ford Ian, Gaw Allan, Hyland Michael, Jukema J Wouter, Kamper Adriaan M, Macfarlane Peter W, Jolles Jellemer, Perry Ivan J, Sweeney Brian J, Twomey Cillian

Abstract excerpt

OBJECTIVE: To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women. DESIGN: Prospective study. SETTING: Scotland, Ireland, and the Netherlands. PARTICIPANTS: Five thousand eight hundred four subjects aged 70 to 82 from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). MEASUREMENTS: Subjects were assessed at baseline and over a mean 3.2-year...

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Identifiers

PMID: 17979899
DOI: 10.1111/j.1532-5415.2007.01415.x

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