Article
Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays.
Science (New York, N.Y.) - 2 Dec 1994
Schiestl R H, Khogali F, Carls N
Abstract excerpt
Deletions and other genome rearrangements can be caused by radiation and are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (p(un)) mutation in the mouse is caused by a gene duplication and reverts to wild type by deletion of one copy. Reversion events in the mouse embryo were detected as black spots on the fur of the animals or microscopically as partially black hair in a...
Topics
- Animals
- Dose-Response Relationship, Radiation
- Embryo, Mammalian
- Female
- Gene Deletion
- Hair Color
- Male
- Maternal Exposure
- Melanocytes
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains