Article
Susceptibility of proliferating cells to benzo[a]pyrene-induced homologous recombination in mice.
Carcinogenesis - 1 Apr 2001
Bishop A J, Kosaras B, Carls N, Sidman R L, Schiestl R H
Abstract excerpt
The pink-eyed unstable mutation, p(un), is the result of a 70 kb tandem duplication within the murine pink-eyed, p, gene. Deletion of one copy of the duplicated region by homologous deletion/recombination occurs spontaneously in embryos and results in pigmented spots in the fur and eye. Such deletion events are inducible by a variety of DNA damaging agents, as we have observed previously with both fur- and...
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