Article
Persistent induction of somatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage.
Radiation research - 1 Jun 2002
Shiraishi Kazunori, Shimura Tsutomu, Taga Masataka, Uematsu Norio, Gondo Yoichi, Ohtaki Megu, Kominami Ryo, Niwa Ohtsura
Abstract excerpt
Untargeted mutation and delayed mutation are features of radiation-induced genomic instability and have been studied extensively in tissue culture cells. The mouse pink-eyed unstable (p(un)) mutation is due to an intragenic duplication of the pink-eyed dilution locus and frequently reverts back to the wild type in germ cells as well as in somatic cells. The reversion event can be detected in the retinal pigment...
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