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Article

Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.

Journal of virology - 1 Jan 1995

Johannsen E, Koh E, Mosialos G, Tong X, Kieff E, Grossman S R

Abstract excerpt

Expression of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) oncogene is regulated by the EBV nuclear protein 2 (EBNA-2) transactivator. EBNA-2 is known to interact with the cellular DNA-binding protein J kappa and is recruited to promoters containing the GTGGGAA J kappa recognition sequence. The minimal EBNA-2-responsive LMP-1 promoter includes one J kappa-binding site, and we now show that...

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Identifiers

PMID: 7983717
DOI: 10.1128/JVI.69.1.253-262.1995
PMCID: PMC188571

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