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Article

Nasopharyngeal carcinoma-associated Epstein-Barr virus-encoded oncogene latent membrane protein 1 potentiates regulatory T-cell function.

Immunology and cell biology - 1 Jul 2007

Pai Saparna, O'Sullivan Brendan, Abdul-Jabbar Ibtissam, Peng Judy, Connoly Geoff, Khanna Rajiv, Thomas Ranjeny

Abstract excerpt

Sequence variation in the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) oncogene structure may affect antigen-presenting cell (APC) function of infected B cells and immune escape by EBV-specific T cells and thus contribute to the development of malignancy. Normal B cell-associated LMP1 (B-LMP1) upregulates B cell APC function through activation of the necrosis factor (NF)-kappaB subunit, RelB. We...

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PMID: 17372611
DOI: 10.1038/sj.icb.7100046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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